A pilot study of leakage and compartmentalization of the contrast agent Ablavar

نویسندگان

  • Octavia Bane
  • Daniel C Lee
  • Brandon Benefield
  • Michael Markl
  • James Carr
  • Timothy J Carroll
چکیده

Methods Simulation study: In vitro studies have shown Ablavar to be 80-90% bound to albumin, with up to 10 fold relaxivity difference between bound and free fractions. We performed simulations to assess the effect of extravasation of the free fraction on signal. Vascular fraction measurements were simulated assuming slow two-compartment exchange for different contrast agent injection concentrations, binding fractions, bound and free relaxivity, and true vascular fractions. Volunteer study: five healthy volunteers (4 males, average age 33) underwent T1 measurement pre and 2 minutes post administration of five injections of 0.006 mmol/kg (a fifth of a single dose) Ablavar. Steady-state T1 was mapped using a cardiac gated Modified Look Locker Inversion Recovery (MOLLI) pulse sequence (slice thickness 8 mm, FOV 300 x 400 mm, matrix 256 x 172, effective TI 100 ms). Image Processing: Maps of vascular fraction were calculated from signal difference maps, according to a slow water exchange model. Fv was measured in the myocardium, dome of the liver, and skeletal muscle visible on the short axis MOLLI images, and was corrected for Ablavar extravasation based on the leakage study. The true fv and exchange rate of water protons was determined by chi square minimization between data and simulations of the effect of water exchange on fv according to the two compartment water exchange model presented by Donahue et al. (1996).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An in vitro study of wet-bonding fissure sealant micro-leakage (Embrace)

An in vitro study of wet-bonding fissure sealant micro-leakage (Embrace) Dr. T. Masoum *- Dr. SH. Kasraie ** - Dr. M. Nafarie *** *Assistant Professor of Pedodontics Dept., Faculty of Dentistry, Hamedan University of Medical Sciences. **Assistant Professor of Operative Dentistry Dept., Faculty of Dentistry, Hamedan University of Medical Sciences. *** Dentist. Abstract Background and Aim: It has...

متن کامل

Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent

Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage ...

متن کامل

Synthesis and evaluation of chitosan manganese-ferrite nanoparticles as MRI contrast agent

Magnetic nanoparticles are the good choice for using in MRI as the contrast agent. Iron oxide particles such as magnetite (Fe3O4) or its oxidized form maghemite (γ-Fe2O3) are the most commonly employed in biomedical applications. In this study, we synthesized and optimized the preparation of chitosan manganese-ferrite nanoparticles (CMn-Fe nps) and evaluated its ability for the mice macrophage ...

متن کامل

A novel MRI contrast agent synthesized by ion exchange method

Objective: In this study, the zeolite-coated iron oxide nanoparticles were evaluated as MRI contrast agent and effect of the nanocomposite synthesis method on MRI contrast was tested. Materials and Methods: Ion exchange method was used for synthesis of iron oxide-zeolite and the as prepared nanocomposite was characterized by XRD, FESEM and TEM. The nanocomposite toxicity in the cell culture, a...

متن کامل

A New Potential Contrast Agent for Magnetic Resonance Imaging: Iron Oxide-4A Nanocomposite

Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.Materials and Methods: Iron oxide–4A nanocomposite (F4A) was syn...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2013